Understand and reduce venlafaxine withdrawal

Outro is a virtual clinic that helps you safely stop Effexor (venlafaxine), minimizing withdrawal symptoms with neurobiology-based methods.

Science-based Effexor taper plans

Support from board-certified clinicians

Relapse-prevention strategies

Non-drug mental wellness practices

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Minimize withdrawal symptoms

Our evidence-based methods are based on neurobiology, and designed to minimize withdrawal symptoms from antidepressants.

Reduce symptom relapse

Through personalized tapering plans and holistic education, Outro clinicians help you reduce your risk of depression or anxiety relapse.

Build holistic well-being

Sustainability is key, and that's why we provide a suite of holistic health resources around topics like mindfulness, nutrition and movement.

Taper Management

A complete program for managing venlafaxine withdrawal

Hyperbolic tapering plans

A neurobiology-based taper method that we personalize to each patient, based on factors like medication type and duration of use.

Ongoing clinician support

With monthly virtual visits and asynchronous messaging, clinicians trained in deprescribing support you through every step of your taper.

Custom medication sizes

Access to compounded prescriptions through our expert clinicians, to ensure your dose sizes match your taper plan.

Non-drug mental wellness

Content, education and support in developing sustainable non-drug techniques like mindfulness, nutrition, movement and sleep.

How It works

Build your personalized plan to wean off venlafaxine

Meet your Outro clinician

Answer a brief series of questions and get paired with a licensed Outro clinician, who will review your information to see if our tapering program is right for you.

Build your taper plan

If deemed eligible, work with your Outro clinician to build a personalized, neurobiology-based plan to taper off your medication safely and successfully.

Taper off with support

Join Outro's taper management program to receive ongoing support to adjust your doses, monitor withdrawal symptoms, and build new lifestyle practice.

"I was stuck on SSRIs for 10 years. I had tried to get off a dozen times. Each time, I had terrible withdrawal symptoms, including suicidal ideation, insomnia, brain zaps, and persistent and debilitating anxiety and depression. Using Outro's method, I was able to get off SSRIs without any of those symptoms that plagued my previous attempts. I am so grateful to the team for their work—I wouldn't have been able to do it alone."

Mark F.

Outro Patient

"My experience with Outro has been nothing short of amazing. I've bene on an antidepressant for the better part of 10 years, and getting off it was never a discussion. From the beginning, the Outro team listened to my needs and built a tapering plan that worked for me. I've never been this confident in a decision for my mental health. Thank you Outro!"

Ariella S.

Outro Patient

Who We Are

Meet some of our deprescribing experts

Dr. Mark Horowitz | Expert in antidepressant tapering and withdrawal
Mark Horowitz, MD
Co-Founder

Dr. Horowitz is the world-leading expert in deprescribing. Drawing from his personal experience and academic research, his work has informed international guidelines on safely stopping psychiatric medications.

Charlotte Herring NP | Outro Health
Charlotte Herring
Lead Nurse Practitioner

Charlotte is a nurse practitioner, health coach and mindfulness facilitator, highly experienced in providing high-quality care via telemedicine. She is passionate about helping patients build holistic  strategies for sustainable mental well-being.

Dr. Bryan Shapiro | Outro Health
Bryan Shapiro, MD
Medical Director

Dr. Shapiro is a board-certified psychiatrist, holding an academic position at UC Irvine Medical Center. He was involved in the conceptualization on hyperbolic tapering, driven by his own lived experience with antidepressant withdrawal.

Adele Framer | Outro Health
Adele Framer
Peer Support Advisor

Adele is a patient advocate and lay expert in tapering and withdrawal, having founded the website Surviving Antidepressants, as well as the Psychotropic Deprescribing Council, a nonprofit organization for research and education.

Who We Are

Meet some of our experts in deprescribing

Dr. Mark Horowitz | Expert in antidepressant tapering and withdrawal

Dr. Mark Horowitz

Dr. Horowitz is the world-leading expert in deprescribing. Drawing from his personal experience and academic research, his work has informed international guidelines on safely stopping psychiatric medications.

Dr. Mark Horowitz | Expert in antidepressant tapering and withdrawal

Charlotte Herring, NP

Charlotte is a nurse practitioner, health coach and mindfulness facilitator, highly experienced in providing high-quality care via telemedicine. She is passionate about helping patients build holistic strategies for sustainable mental well-being.

Dr. Mark Horowitz | Expert in antidepressant tapering and withdrawal

Dr. Bryan Shapiro

Dr. Shapiro is a board-certified psychiatrist, holding an academic position at UC Irvine Medical Center. He was involved in the conceptualization on hyperbolic tapering, driven by his own lived experience with antidepressant withdrawal.

Dr. Mark Horowitz | Expert in antidepressant tapering and withdrawal

Adele Framer

Adele is a patient advocate and lay expert in tapering and withdrawal, having founded the website Surviving Antidepressants, as well as the Psychotropic Deprescribing Council, a nonprofit organization for research and education.

Common questions

Common questions about Outro, tapering and Effexor (venlafaxine) withdrawal.

What if I've tried to stop before?

Many people have difficulties when they try to go off Effexor (venlafaxine), largely due to tapers that are too fast and lead to withdrawal symptoms. Our team of clinicians, trained in evidence-based tapering, will work with you to develop a tailored program that's informed by the latest scientific evidence and designed to minimize withdrawal effects - even for people who have tried to stop before.

How is Outro different?

Safely stopping Effexor (venlafaxine) requires a comprehensive approach that is often difficult for an individual prescriber to provide, due to the time required and lack of knowledge. The knowledge of the latest techniques in tapering Effexor, pioneered by our co-founder and patient advisors, are only just starting to be taught in medical schools. So, with all that said, think of Outro as a specialist in safe, neurobiology-based tapering.

What is hyperbolic tapering?

Hyperbolic tapering is based on the fact that, as antidepressant dose goes up, the a drugs affect on the brain decreases. In research, this forms the graph of a hyperbolic curve. This means that, as you go down closer to zero milligrams of a drug, each dose change has a bigger affect on the brain and increases the risk of withdrawal symptoms. At Outro, we personalize this method to your medication, duration of use, and more, to help you taper at a rate you can tolerate.

What is a personalized tapering plan?

A personalized, hyperbolic tapering plan for a drug like Effexor (venlafaxine) would take into account the half-life of the medication, how long you've used it, any previous experience of withdrawal symptoms, your current life situation, and other factors that one of our clinicians will take into account to ensure it fits your needs. With ongoing support and symptom monitoring, your taper plan can be paused or adjusted as needed.

Take the first step

Meet with a member of Outro's team to learn more.