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Providing an alternative to drug-centered mental healthcare
At Outro, we're building the solution that many of our team members wish they'd had when deciding to discontinue their medications. Our dedication stems from a deep appreciation for good science and patient choice.
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Our story
From pioneering peer support groups to rewriting national guidelines
Outro co-founder Dr. Mark Horowitz was prescribed an antidepressant while in medical school, on his way to earning a PhD in the neurobiology of depression and the pharmacology of antidepressants. Years later, as a training psychiatrist in the UK, Mark followed traditional guidance to wean himself off his antidepressant, only to experience panic attacks, sleep disruptions, and a depression far worse than anything he had experienced before.
Left searching for solutions, Mark found an online community of thousands of others in similar situations. Founded by Adele Framer, an advisor to Outro, this community inspired Mark’s research into safely stopping antidepressants and the development of hyperbolic tapering, which the backbone of Outro’s individualized tapering plans. In 2024, Dr. Horowitz published the Maudsley Deprescribing Guidelines—the first textbook dedicated outlining neurobiology-based principles and approaches to safely stopping various psychotropic medications.
Having had her own difficulties going off an antidepressant, Adele has dedicated more than a decade to being a lay researcher in and patient advocate for safe tapering, counselling more than 10,000 people through their journeys off medication. We draw on Mark and Adele’s world-leading knowledge to support our team in providing the highest level of care and safety to our members.
Fast forward to today, hyperbolic tapering is now endorsed by national authorities in the United Kingdom and, in 2024, Dr. Horowitz published the Maudsley Deprescribing Guidelines—the first textbook dedicated outlining neurobiology-based principles and approaches to safely stopping various psychotropic medications.
Hyperbolic Tapering
A new method, based on neurobiology
Today, Outro is building the first tech-enabled, comprehensive service for helping millions of people safely discontinue their psychiatric medications. This includes not only providing tapering services, but also developing research and awareness around withdrawal, safe tapering, and the promise of more sustainable approached to mental well-being.
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Based on the latest evidence
Our evidence-based methods are based on neurobiology, and designed to minimize withdrawal symptoms from antidepressants.
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Grounded in neurobiology
Through personalized tapering plans and holistic education, Outro helps reduce your risk of depression or anxiety relapse.
Designed to reduce withdrawal
Sustainability is key, and that's why we provide a suite of holistic health resources around topics like mindfulness, nutrition and movement.
Meet our clinical team
Here are some of the faces building the alternative to drug-centered care
Dr. Horowitz is the world-leading expert in deprescribing. Drawing from his personal experience and academic research, his work has informed international guidelines on safely stopping psychiatric medications.
Dr. Shapiro is a board-certified psychiatrist, holding an academic position at UC Irvine Medical Center. He was involved in the development of hyperbolic tapering, driven by his research and own experience with antidepressant withdrawal.
Charlotte is a nurse practitioner, health coach and mindfulness facilitator, highly experienced in providing high-quality care via telemedicine. She is passionate about helping patients build holistic strategies for sustainable mental well-being.
Dr. Hicks is a psychiatrist who combines evidence-based tapering methods with holistic approaches, drawing on mindfulness and integrative healing. Her work is grounded in compassion, honesty, and a deep respect for each patient’s unique path to mental well-being.
Kayleigh has over 15 years of experience across diverse clinical settings. Her work is shaped by a deep interest in mental health, substance use disorders, and functional medicine. She offers compassionate, evidence-based care, meeting each patient where they are and supporting meaningful, lasting change.
Dr. Kalika is a California-based psychiatrist who has been providing clinical care for over 9 years. At Outro, he supports clinicians in navigating the pharmacology and psychology of safe deprescribing and overall patient well-being.
Marissa is a public health professional with over 9 years of experience in patient and customer services, bringing a systems-oriented perspective to her work. Marissa specializes in public health communication, behavior change, and program coordination, with a focus on mental health and health equity.
Available in several states and growing
Outro is now accepting patients in several states and actively planning expansion. If you don't see your state here, join the waitlist via the onboarding flow.